Research Interests
The Aspden Group are interested in RNA and its role in gene expression. We broadly address questions on the regulation of mRNA translation, non-coding RNA function and the role of specific RNA-protein complexes. Using a combination of biochemistry, genomics, molecular biology and genetics to study RNAs both in Drosophila melanogaster and several mammalian systems.
Many of the regulatory processes and RNA-binding proteins are highly conserved between Drosophila and mammals. This research focus is of general interest and importance because disruptions to RNA-protein interactions and translational regulation play significant roles in a variety of cancers and other disorders (e.g. spinal muscular atrophy) and many non-coding RNAs show correlations with neuronal disease phenotypes but their role in cellular mis-function has not been elucidated. Addressing the dynamic nature of RNPs may also shed some light on why changes in RNA-binding protein levels are frequently altered in cancerous cells. |
The Aspden Lab is funded by:
Previous sources of funding:
MRC New Investigator Research Grant
(2016-2019) |
Wellcome Trust Institutional Strategic Support
Fund Pump Priming (2016-2017) |